A Modular Pipeline for Any Project

Link Explorer (LinX) is a fully modular pipeline that can be customized to handle cross-linking mass spectrometry projects of any scope and size.

LinX has been built from the ground up with multithreaded processing and interactive visualizations for rapid results analysis.

LinX Pipeline Diagram

LinX Customization

Database Connections

Bring on the "Big Data"

Cloud Infrastructure

Rent as much horsepower as you need

Automated Reporting

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Web Accessibility

View interactive reports over the internet

News

LinX Beta 1 Development

Closed Beta

  • Web-based and interactive spectra visualization

  • Interactive data visualization and analysis options

  • Integration of custom data handling rules and cross-linking reagent masses (cleavable and non-cleavable)

  • Interface to Protein Prospector for database searching

Publication

Cross-linking Mass Spectrometry
Kao A. et al.

"Although cross-linking coupled with mass spectrometry (MS) has been presented as a feasible strategy for structural elucidation of large multisubunit protein complexes, this method has proven challenging because of technical difficulties in unambiguous identification of cross-linked peptides and determination of cross-linked sites by MS analysis. In this work, we developed a novel cross-linking strategy using a newly designed MS-cleavable cross-linker....
....
Given its effectiveness and simplicity, this cross-linking strategy can find a broad range of applications in elucidating the structural topology of proteins and protein complexes."

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