A Modular Pipeline for Any Project
Link Explorer (LinX) is a fully modular pipeline that can be customized to handle cross-linking mass spectrometry projects of any scope and size.LinX has been built from the ground up with multithreaded processing and interactive visualizations for rapid results analysis.
LinX Customization
Database Connections
Bring on the "Big Data"
Cloud Infrastructure
Rent as much horsepower as you need
Automated Reporting
Receive updates via SMS text or email
Web Accessibility
View interactive reports over the internet
LinX Beta 1 Development
Closed Beta
Web-based and interactive spectra visualization
Interactive data visualization and analysis options
Integration of custom data handling rules and cross-linking reagent masses (cleavable and non-cleavable)
Interface to Protein Prospector for database searching
Cross-linking Mass SpectrometryKao A. et al.
"Although cross-linking coupled with mass spectrometry (MS) has been presented as a feasible strategy for structural elucidation of large multisubunit protein complexes, this method has proven challenging because of technical difficulties in unambiguous identification of cross-linked peptides and determination of cross-linked sites by MS analysis. In this work, we developed a novel cross-linking strategy using a newly designed MS-cleavable cross-linker.... .... Given its effectiveness and simplicity, this cross-linking strategy can find a broad range of applications in elucidating the structural topology of proteins and protein complexes."